Substance Misuse Prevention

This program takes an evidence-based shared risk and protective factor approach to preventing substance misuse in Colorado. Applicants can select to implement Communities That Care, a proven community organizing model that guides communities through a proven five-phase change process. Or applicants can select one of many upstream policy change strategies to implement locally, helping to reduce risk for future substance misuse among youth.

Using prevention science as its base, the program promotes healthy youth development, improves youth outcomes, and reduces problem behaviors.

New funding opportunity

A new request for applications (RFA #32174) is available for funding two options to address substance misuse prevention using a shared risk and protective factor approach (July 2021 through June 2026). 

For more information on grant writing:

Get involved

Contact the listed grantee in your area to learn more about opportunities to get involved.

  • Communities That Care in Colorado contact list (grant period 2016-2021)

Risk and Protective Factor Profiles

State and regional profiles on scientifically-validated risk and protective factors that influence the likelihood of substance abuse, violence, and mental well-being outcomes. These scaled indicators use data from the 2017 Healthy Kids Colorado Survey (HKCS) pertinent to taking an evidence-based approach to prevention and implementing the Communities That Care (CTC) model.


CDPHE received funding from the marijuana tax cash fund to support substance abuse prevention among youth using a shared risk and protective factor approach. Communities That Care is a community-based prevention model that was evaluated across the country with significant results, including preventing youth substance use initiation and youth crime and violence. This model helps local communities assess the specific risk and protective factors among the youth in their communities. The communities then pick from a menu of effective, evidence-based programs and strategies to address the specific needs of local youth.

Contact us

Submit a question to the Colorado Substance Misuse Prevention coaching team.