Elevating Prevention In Colorado (EPIC) Grant Funding

Elevating Prevention In Colorado (EPIC) Grant Funding RFA # 49960377 Announcement

September 22, 2025: CDPHE is excited to announce the new round of funding from 2026 - 2031 (5-year cycle) in the Fall of 2025. A new Request for Applications (RFA) #49960377 is available to fund communities addressing substance use/misuse primary prevention using a shared risk and protective factor approach, starting July 2026 through June 2031.

The EPIC grant funding opportunity, RFA #49960377, empowers communities to establish a collective impact system that fosters comprehensive primary prevention efforts for substance use and misuse, aligning with community needs.

CDPHE's prevention goals are to support communities by combining different funding sources at the state level to meet community needs through promotion and primary prevention, tackling the root causes of substance use in Colorado.

To apply for RFA#49960377, please follow the instructions and submit your application electronically by 5 p.m. MDT, Monday, November 3, 2025. 
Please continue to check this webpage throughout the application period for additional information and updates on RFA#49960377.

New Pre-application webinar date

CDPHE will host a webinar to outline the EPIC RFA and address questions. The webinar is now scheduled for Friday, October 3, 2025, from 10 to 11:30 a.m. MDT. You can register and join the webinar using the registration link. Attending the pre-application webinar is optional. The webinar will be recorded. *Please note, for those who have already registered for the original October 2 date that was posted, an updated meeting date and time will be sent to you. 

• Pre-application Webinar Registration. (Zoom)

Don’t forget to continue checking for updated documents and information. We apologize for any inconvenience this may cause.

Pre-application webinar recording

Thank you to those who attended the Pre-application Webinar. If you were unable to attend and would like to access the information, you can view the recording and slides in the EPIC RFA#49960377 Application Documents Folder.
 

EPIC RFA#49960377 Application Documents

Submission instructions

Please refer to the submission instructions. CDPHE will only accept electronic submission of applications.

This Request for Applications (RFA) is issued by the Colorado Department of Public Health and Environment (CDPHE), also referred to as the "State". The CDPHE contact listed in these instructions is the sole point of contact concerning this RFA. 

1. During the solicitation process for this RFA, all official communication with applicants will be via notices on the CDPHE program websites listed in the schedule of activities. Notices may include any modifications to administrative or performance requirements, answers to inquiries received, clarifications to requirements, and the announcement of the apparent winning applicants. Applicants are responsible for monitoring for publication of modifications to this solicitation. It is incumbent upon applicants to carefully and regularly monitor for any such notices. Applicants are not to contact any other state office or individual regarding this RFA or this project. Applicants are not to rely on any other statements that alter any specification or other term or condition of the solicitation.
2. Applications must be received on or before the due date and time as indicated in the Schedule of Activities. Late applications may not be accepted. It is the responsibility of the applicant to ensure that its application is received by CDPHE listed in these instructions, on or before the due date and time.
3. One completed copy of the Request for Application Cover Sheet & Signature Page must be signed digitally or in ink, preferably blue ink, by a person who is legally authorized to bind the applicant to the application. Submissions that are determined to be at a variance with this requirement may be deemed non-responsive and may not be accepted.
4. All materials submitted shall become the property of the CDPHE.

Instructions for electronic application

• The Application must be received electronically by no later than the due date and time indicated on the cover page of this document. Faxed applications will not be accepted. Fill out the EPIC Application Form and attach the required attachments to the form.
  • All attachments must be uploaded to SurveyMonkey as a PDF. This includes your budget workbook, as SurveyMonkey does not accept Excel files. Export your Excel budget workbook to a PDF. Make sure that all of the necessary sheets are fully visible in the PDF. Do not include any instructions or examples in the file. If needed, adjust the page orientation to landscape.
  • Clearly name each attachment with your organization's name followed by the attachment label.
    • For example, if your organization is Athena, label Attachment A as "Athena Attachment A."
  • Applications received through the electronic application form will receive a message confirming the delivery.
     

Inquiries

Applicants may make written inquiries in the Elevating Prevention In Colorado (EPIC) RFA Question Submission form to obtain clarification of requirements concerning the RFA. Responses to applicant inquiries will be published as an outline in the Schedule of Activities by October 17, 2025, at 5 p.m. MST. No questions will be accepted after this date and time.

• Applicants will be asked to write out the question and include the section number and paragraph number from the EPIC RFA to which your inquiry applies.
• Responses to applicant inquiries will be published as an outline in the Schedule of Activities by the close of business on the date indicated. Applicants are not to rely on any other statements that alter any specification or other term or condition of the RFA. 
• Any questions about accessing, completing, or submitting this application must be submitted via the RFA Question Submission survey. Be sure to leave contact information for follow-up.
• After October 17, 2025, at 5 p.m. MST, general or content-related questions about the EPIC application (e.g., eligibility, requirements) will no longer be answered.
   

Responses 

• RFA#49960377 Questions and Answers. (Google sheet)

Please Note the New Pre-Application Webinar Date

CDPHE will host a webinar to outline the EPIC RFA and address questions. The webinar is scheduled for Friday, October 3, 2025, from 10 to 11:30 a.m. MDT. You can register and join the webinar using the registration link. Attending the pre-application webinar is optional.

*Please note, for those who have already registered for the original October 2 date that was posted, an updated meeting date and time will be sent to you.

• Pre-application Webinar Registration. (Zoom)

Pre-application webinar recording

Thank you to those who attended the Pre-application Webinar. If you were unable to attend and would like to access the information, you can view the recording and slides in the EPIC RFA#49960377 Application Documents Folder.